Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

Human Male Sex: Endocrine Disruption and Male Reproductive Wellness

9.1 Introduction

Male sexuality is decided genetically during the time of fertilization because of the existence of a Y chromosome into the spermatozoan since it fuses with all the X-chromosome-containing ovum, while the region that is sex-determining of Y chromosome (SRY) then drives the bipotential gonad associated with embryo to be a testis through hormone-independent mechanisms 1,2. But, after the very early testis is created, growth of the total male phenotype, including further testicular development (masculinization), becomes entirely determined by a complex community of hormonal signals, particularly hormones secreted through the testes 2. People who lack any gonads are phenotypically female 1 and intervention that is endocrine expected to alter the standard feminine phenotype to be male 2. This will make both development and upkeep of masculinization in danger of endocrine-disrupting impacts after all developmental phases from very very early embryo to adulthood; in particular, interruption of very very early embryonic developmental procedures could have consequences for male reproductive health in adult life 2. Continuar lendo Human Male Sex: Endocrine Disruption and Male Reproductive Wellness